2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N9535A
    (R)-tert-OMe-byakangelicin
    (R)-tert-OMe-byakangelicin is a kind of furanocoumarin, which has inhibitory activity to liver drug metabolizing enzyme (DME) activity. (R)-tert-OMe-byakangelicin can be isolated from immature fruits of Angelica sinensis.
    (R)-tert-OMe-byakangelicin
  • HY-137544
    16-Phenyl tetranor Prostaglandin F2α
    16-phenyl tetranor Prostaglandin F2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
    16-Phenyl tetranor Prostaglandin F2α
  • HY-W158239
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid is a metabolite of GW 501516 (HY-10838).
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
  • HY-135595
    6-Raloxifene-β-D-glucopyranoside
    6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A.
    6-Raloxifene-β-D-glucopyranoside
  • HY-136445R
    Terbuthylazine-desethyl (Standard)
    Terbuthylazine-desethyl (Standard) is the analytical standard of Terbuthylazine-desethyl. This product is intended for research and analytical applications. Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide).
    Terbuthylazine-desethyl (Standard)
  • HY-128696R
    Amlodipine aspartic acid impurity (Standard)
    Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension.
    Amlodipine aspartic acid impurity (Standard)
  • HY-139268
    (±)7(8)-EpDTE
    (±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid.
    (±)7(8)-EpDTE
  • HY-136347
    3α-Hydroxy pravastatin sodium
    		99.35%
    3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor.
    3α-Hydroxy pravastatin sodium
  • HY-116016R
    Etilevodopa (Standard)
    Chlorbenside (Standard) is the analytical standard of Chlorbenside. This product is intended for research and analytical applications. Chlorbenside is an organochlorine pesticide. Chlorbenside targets organism such as mites and ticks and possesses efficient ovicidal and larvicidal activities.
    Etilevodopa (Standard)
  • HY-119359
    5,6-Epoxy-13-cis retinoic acid
    5,6-Epoxy-13-cis retinoic acid (Isotretinoin EP impurity G) is a metabolite of 13-cis retinoic acid.
    5,6-Epoxy-13-cis retinoic acid
  • HY-143907S
    Atorvastatin EP impurity H-d5
    Atorvastatin EP impurity H-d5 is the deuterium labeled Atorvastatin EP impurity H.
    Atorvastatin EP impurity H-d<sub>5</sub>
  • HY-147327
    N-Formylsarcolysine
    N-Formylsarcolysine has antitumor activity, and inhibits leukemia by increasing the Hb and erythrocyte levels and decreasing the number of leukocytes. N-Formylsarcolysine also involves in glioblastoma and other diseases research.
    N-Formylsarcolysine
  • HY-W011235R
    Norfluoxetine hydrochloride (Standard)
    Arecoline (hydrobromide) (Standard) is the analytical standard of Arecoline (hydrobromide). This product is intended for research and analytical applications. Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress.
    Norfluoxetine hydrochloride (Standard)
  • HY-W050000R
    OR-1855 (Standard)
    Tanshinone IIA sulfonate (sodium) (Standard) is the analytical standard of Tanshinone IIA sulfonate (sodium). This product is intended for research and analytical applications. Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.
    OR-1855 (Standard)
  • HY-137773
    N-Methyl pemetrexed
    N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer.
    N-Methyl pemetrexed
  • HY-118548
    Tetranor-PGAM
    Tetranor-PGAM is a tetranor-prostaglandin A metabolite. Tetranor-PGAM is a dehydration product of tetranor-PGEM (HY-114988). Tetranor-PGAM can be measured as a surrogate for tetranor-PGEM levels in urine.
    Tetranor-PGAM
  • HY-148051
    Ilaprazole sulfone
    Ilaprazole sulfone is the major metabolite of Ilaprazole (HY-101664), is predominantly catalysed by CYP3A4/5. Ilaprazole (IY-81149) is an orally active proton pump inhibitor.
    Ilaprazole sulfone
  • HY-W002112S1
    (±)-Nornicotine-d7
    (±)-Nornicotine-d7 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine-d<sub>7</sub>
  • HY-113478R
    3β-Ursodeoxycholic acid (Standard)
    3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA.
    3β-Ursodeoxycholic acid (Standard)
  • HY-143982S
    Mianserin EP impurity E-d4 hydrochloride
    Mianserin EP impurity E-d4 (hydrochloride) is the deuterium labeled Mianserin EP impurity E hydrochloride.
    Mianserin EP impurity E-d<sub>4</sub> hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity